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队伍概况

姓名: 柯少勇
所在单位: 生农中心
职称/职务: 副研究员
学科专业: 应用化学
研究方向: 农药化学
联系电话: 02759101956
电子信箱: keshaoyong@163.com
主要学习及工作经历:

2005.9-2009.3  华东理工大学  应用化学  博士
2002.9-2005.7  上海师范大学  有机化学  硕士
1998.9-2002.7  华中师范大学  化    学  学士

主要社会兼职情况:

目前担任国际期刊Chemical Biology Letters、Academia Journal of Agricultural Research杂志编委;美国化学会、欧洲药学会、中国化学会及Elsevier、SpringLink、Bentham、Taylor and Francis等国际出版社主办的二十余种SCI源刊论文及书稿评审专家;波兰项目通讯评审专家;中国科技论文在线特聘专家。

目前主要研究领域:

农药化学、药物化学、绿色高效合成方法学

主持及参与项目(课题)情况(主要科技项目5项):

1、PI3K/Akt信号通路在DHEA衍生物抗EV71中的作用研究(31400153),国家自然科学基金,2015-2017;
2、微生物源农药先导化合物的研究,国家科技支撑计划(2011BAE06B004-02),2011-2015;
3、天然抑菌活性3-酰基吡咯烷-2,4-二酮类似物的合成与性质研究(2011BAE06B004-15),国家科技支撑计划,2011-2015;
4、基于Ryanodine受体类绿色杀虫剂的设计合成及活性研究,湖北省农业科学院青年科学基金(2011NKYJJ19),2012-2013;
5、植物精油导向的手性菊酯类似物合成及杀虫活性研究(31101467),国家自然科学基金,2012-2014。

获得的科技奖励及专利、标准情况:

1、Ke SY, et al. Conjugated diene derivatives, preparation method therefor, and uses thereof as anticancer drug. PCT Intl. Appl. WO2015021833A1, 2015.
2、柯少勇等. 具有杀虫活性的肟醚或酯衍生物及其制备方法与应用. 中国专利, 授权专利号: ZL201010518800.4, 2014.
3、柯少勇等. 具有双腙结构的甾体衍生物作为抗病毒药物的应用. 中国专利, 申请号: 201410053947.9, 2014.
4、柯少勇等. 共轭双烯衍生物及其制备方法与作为抗癌药物的用途. 中国专利, 申请号: 201310350441.X, 2013.
5、 Ke SY, et al. Nitrogenous Heterocyclic Imide Derivative and Preparation Method and Use Thereof. PCT Intl. Appl. WO2013177985A1, 2013.
6、柯少勇等. 含氮杂环亚胺衍生物及其制备方法和用途. 中国专利, 申请号: 201210171077.6, 2012.

代表性著作及论文发表情况:

Yang ZW, Zhang ZG, et al., Multisubstituted indole-acrylonitrile hybrids as potential cytotoxic agents, Bioorg. Med. Chem. Lett., 2014, 24, 1907.
Wei YH, Shi LQ, Wang KM, Liu ML, Yang QY, Yang ZW*, Ke SY*, Discovery of gramine derivatives that inhibit the early stage of EV71 replication in vitro, Molecules, 2014, 19, 8949.
Ke SY,Wei YH, Shi LQ, et al.,Synthesis of novel steroid derivatives derived from dehydroisoandrosterone as potential anticancer agents, Anti-Cancer Agents Med. Chem.,2013, 13, 1291.
Ke SY, Wei YH, Yang ZW, et al.,Novel cycloalkylthiophene-imine derivatives bearing benzothiazole scaffold: Synthesis, characterization and antiviral activity evaluation, Bioorg. Med. Chem. Lett., 2013, 23, 5131.,
Ke SY,Zhang ZG, Long T, et al.,Novel salicylamide derivatives incorporating neonicotinoid pharmacophore: Design, synthesis, characterization, and biological evaluation, Med. Chem. Res., 2013, 22, 3621.
Ke SY, Shi LQ, Cao XF, et al., Heterocycle-functional gramine analogues: Solvent and catalyst-free synthesis and their inhibition activities against cell proliferation, Eur. J. Med. Chem., 2012, 54, 248.
Shi LQ, Hu R, Wei YH, Liang Y, Yang ZW, Ke SY*, Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anti-cancer agents: Design, synthesis and biological evaluation, Eur. J. Med. Chem., 2012, 54, 549.
Ke SY, Zhang YN, Shu WM, et al., Structural diversity-guided convenient construction of functionalized polysubstituted butenolides and lactam derivatives, C.R. Chim., 2011, 14, 1071.
Ke SY, Cao XF, Liang Y, et al., Synthesis and biological properties of oxadiazine-based heterocyclic derivatives, Mini-Rev. Med. Chem. 2011, 11, 642.
Cao XF, Chen CS, Lu WC, Ke SY*, Chiral β-arylalkyl-1H-1,2,4-triazoles as demethylase inhibitors: Biological evaluation and its stereoselective interaction with sterol 14α-demethylase from Penicillium digitatum, Pestic. Biochem. Phys. 2011, 99, 189.
Ke SY, Sun TT, Zhang ZG, et al., Spirodiclofen analogues as potential lipid biosynthesis inhibitors: A convenient synthesis, biological evaluation, and structure-activity relationship, Bull. Korean Chem. Soc. 2010, 31, 2315.
Ke SY, Qian XH*, Li Z, et al., Diacylhydrazine derivatives as novel potential chitin biosynthesis inhibitors: Design, synthesis, and structure-activity relationship, Eur. J. Med. Chem. 2009, 44, 2985.
Ke SY, Liu FY, Wang N, Yang Q, Qian XH*, 1,3,4-Oxadiazoline derivatives as novel potential inhibitors targeting chitin biosynthesis: Design, synthesis and biological evaluation, Bioorg. Med. Chem. Lett. 2009, 19, 332.
Ke SY, Qian XH*, Li Z, et al., Novel 4H-1,3,4-oxadiazin-5(6H)-ones with hydrophobic and long alkyl chains: Design, synthesis, and bioactive diversity on inhibition of monoamine oxidase, chitin biosynthesis and tumor cell, Eur. J. Med. Chem. 2009, 44, 2113.
Ke SY, Li Z, Qian XH*, 1,3,4-Oxadiazole-3(2H)-carboxamide derivatives as potential novel class of monoamine oxidase (MAO) inhibitors: Synthesis, evaluation and role of urea moiety, Bioorg. Med. Chem. 2008, 16, 7565.

备注:1、科技产出主要是近十年以来的成果;
2、院副高职称以上科技(管理)人员填报。